Showing posts with label ancestral origins. Show all posts
Showing posts with label ancestral origins. Show all posts

Tuesday, December 18, 2012

Comparing Admixture Test Results Across Companies (otherwise known as "ethnic" breakdowns): FTDNA, AncestryDNA, 23andMe and Geno 2.0 - My Review

With the recent releases of Geno 2.0 and the new 23andMe Ancestry Composition feature, I thought it would be a good time to review and compare my biogeographical ancestry (BGA) results from each of the major DNA testing companies. (BGA is sometimes referred to as ethnic breakdown or admixture analysis.)

My Known Ancestry
First, let's take a look at what I know of my ancestry:
25% Finnish
12.5% Scandinavian (Norway)
12.5% British (England)
~25% Colonial New England (presumably mostly British)
~15.63% Unknown (due to brick walls and immigrant ancestors of unknown origins)
~9.38% German

CeCe's Ancestry Percentages
You can create your admixture pie chart here.





Family Tree DNA's Population Finder
FTDNA's Population Finder (comes with Family Finder) was one of the first commercially available admixture tests based on chip technology.




I am listed as 98.93% Western European (Orcadian) with a 1.31% margin of error. Surprisingly, none of my substantial Finnish ancestry was detected. In my case, Population Finder is not very informative so I am glad that FTDNA will soon be updating this feature. Of course, many people's Population Finder results will be much more detailed than mine, so my experience may not be a typical representation of this feature's capabilities.


AncestryDNA's Genetic Ethnicity
Just a couple of weeks ago, AncestryDNA's admixture tool was the newest entry into the market, but times are changing fast.


It's one thing for results to not be especially informative like Population Finder above, but for them to be downright wrong is disappointing. This feature underestimates my Finnish ancestry and overestimates my Scandinavian ancestry, both substantially.  Because I have tested my mother, I know that they are estimating a large amount of Scandinavian from my mother's side when there is no Scandinavian ancestry in her extensively documented family tree at all. Does that mean that she doesn't have any? Not necessarily, but AncestryDNA estimates that she has 62% Scandinavian and only 23% Finnish (instead of ~50%) ancestry. Although none of these admixture tools are perfect, this one seems to be the most misleading. Notably, I have received many messages from people confounded and even very upset by their AncestryDNA Genetic Ethnicity results.


23andMe's Ancestry Composition
23andMe started out with a very conservative three population breakdown called Ancestry Painting. Customers had long been requesting an updated version. Happily, the brand new Ancestry Composition is much improved. There are three different views and a number of resolution and confidence settings. I prefer the most granular (Sub-regional Resolution) and lowest confidence (Speculative) of those.

Map View:


Chromosome View:

Split View:

This version matches my known ancestry the most closely and is also in line with the ancestral origins represented in my Relative Finder/Family Finder/AncestryDNA match lists. It was fun to see that even my tiny amount of Ashkenazi Jewish ancestry was detected. Although this tool is definitely the most informative and flexible, it isn't without problems in this early version. For example, on the Split View, all of my Finnish should be from my maternal side, but you can see that 4.6% of my estimated 21.5% Finnish is erroneously assigned to my paternal side. Conversely, almost all of my Scandinavian is correctly assigned to my paternal side. Since my deceased father wasn't tested at 23andMe, they had to compute the Split View without my father's results, which makes it more challenging. However, since I have tested both of his siblings there (they don't have any Finnish), advancements in the future may help in this regard.  I have many relatives tested at 23andMe and the vast majority of them have results very much in line with their family trees. Both of my sisters' Ancestry Composition results seem even more accurate than mine, as do my mother's, both of my aunts' and my uncle's. (I may just be a bit of a mutant!)

National Geographic Geno 2.0's Who Am I?
As most of you know, the new phase of the Genographic Project started returning results a couple of weeks ago.  Screen shots show the different components that make up my ancestry according to these results.
































Then, they list the two reference populations that match the combination of my components the most closely. Interestingly, even though I am only one quarter Finnish, they chose Finnish as the first one.

Next, they choose Iberian (Spain and Portugal) as the second population, which doesn't fit with any of my known ancestry.


This admixture tool is different than the other ones reviewed here because it is looking at deep ancestry from thousands of years ago. Personally, as a genealogist, I don't find it as informative or as satisfying as the admixture results that reflect more recent ancestry. I also don't really like how each person's unique combination of ancient components is essentially forced into a single (more recent) population label. This, no doubt, works very well for those whose ancestors have been in one geographic region for hundreds or even thousands of years, but it does not result in highly relevant results for those of us who are highly admixed with ancestry from many different regions. I find the tools that analyze and attempt to categorize small portions of my DNA separately, giving percentages of each region or ethnic group that add up to my total ancestry more meaningful.

Conclusion
At this point in time, for those interested in the origins of their ancestors in the last couple hundred to few hundred years, 23andMe is the best choice in my opinion (especially at the new price of only $99). If your interests are more focused on deep ancestry and anthropology, then Geno 2.0 would be my recommendation. (Remember though that this review is focused on admixture features only. There is much more to take into consideration when purchasing a DNA test for genealogical purposes!)

All of these companies would be well-advised to focus on improving their admixture results for those with non-European ancestry. (Obviously, the majority of their customers have been of primarily European ancestry so far, but optimally everyone will have the the same opportunities of self-discovery in the future.) 23andMe has publicly stated their plans to do so and I'm sure that the other companies will address these shortcomings as well.  AncestryDNA's acquisition of the Sorenson database and National Geographic's vast collection of indigenous population samples puts them in the best position to advance in these areas in the near future, but as 23andMe has demonstrated, customer samples carefully vetted with genealogical information can be utilized with great success as well. As more people are tested, particularly internationally, there will be improvement across the board.

It is important to remember that as intriguing as these admixture predictions are, none of them are 100% accurate at the granular level. We still have a long way to go before anyone can honestly claim to be able to tell a person exactly where their ancestors once lived based on their autosomal DNA alone. However, we are making progress and in a couple of years we will likely be amazed at the advances. In the meantime, the ever-increasing competition between the major companies is proving to be beneficial, spurring all to improve their offerings. So, don't count any of them out quite yet. In a short time, my opinions regarding the "best of" may have completely changed again!


*For more information on these features, please see:

[Disclosure: I have relationships with all of the companies reviewed above. I received complimentary Geno 2.0 and AncestryDNA kits for review purposes. I occasionally receive complimentary 23andMe test kits through my work as a volunteer "23andMe Ancestry Ambassador". Additionally, I have affiliate relationships with Family Tree DNA, 23andMe and AncestryDNA and own a small amount of Ancestry.com stock. I always strive for complete objectivity - none of these relationships have affected the opinions stated in this blog in any way.]

Wednesday, October 17, 2012

Geno 2.0 - It's in the mail!

I was very excited to finally receive my Geno 2.0 kit today. I quickly collected my DNA sample and returned it to National Geographic. I thought I would post a few photos for those of you who are still waiting for your kit.



Upon opening, you get this:


And this:


The swabs are exactly like Family Tree DNA's:


The vials are tucked away at the bottom of the cardboard insert:


To get them out, you need to pull out the cardboard folds at the corners from this:

To this:


The vials also look just like FTDNA's:


Just follow the directions:


Don't forget to fill out the consent form, detach it and mail it back:




After swabbing (I didn't take pictures of that, but Roberta did!), CAREFULLY release the tip of the swab into the solution in the vial by pushing on the end of the swab like this:


Then put the vials in the provided plastic baggie:


And place them in the envelope:


And then mail it back!

Don't forget to register your kit here using the confidential ID found on the inside cover of your kit, your vials and the back of the Quick Start Guide:



And please consider contributing your result to science:




I'm really looking forward to discovering some of the things discussed in the pamphlet:


But I will have to wait awhile:


You can bet I will be checking this ^^ page regularly!



**You can order your kit here.